2.5kg of cannabis has been seized from a vehicle at the Tooleybuc Bridge border checkpoint, as part of New South Wales Police's Operation Border Closure.

Just after midnight on Sunday, officers stopped a white Hyundai Accent on the bridge.

Police spoke to the driver, a 39-year-old woman, and passenger, a 35-year-old man, who were both allegedly unable to produce a valid permit to enter NSW.

During a search of the vehicle, police located 2.5kg of cannabis in the boot. It’s been seized to undergo forensic examination.

The man and woman, from Casula, south-west of Sydney's CBD, have been charged with take part supply cannabis have been refused bail to appear in Dubbo Local Court today.

Meanwhile, police are reminding motorists travelling between New South Wales and South Australia, that they cannot transit through Victoria.

The best direct route to cross the NSW/SA border is via the Barrier Highway at Broken Hill.

If you travel through Victoria, including the border zone – ‘border bubble’ – NSW residents will be denied re-entry into NSW without a current entry permit or authorisation to enter under the Public Health Order.